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Boys School Bullying Girls Slaughtering Animals Mother actually roasted his hands with fire

                    (The original title: son in school abusive animal bullying girl cruel mother actually roasted his hand as punishment)
                   

                                   

[Son in school abusive animal bullying girl cruel mother actually roasted his hands as a punishment] A 6-year-old Miami boy slaughtered animals at school bullied female students, his mother punished him even put his hand on the stove grilled. She was recently prosecuted and arrested by the police for child abuse crimes, but she claimed in an interview that she had the right to do so and that her son was very unruly. She even roared in Spanish: “My son is bad enough to kill animals, what else can I do?” But she did not explain what the son killed or killed. The judge said that even though Colombia may allow it, the United States does not allow such punishment of children. At present, the mother is awaiting trial on the crime of child abuse, and her son’s injury is still unknown.

Japan train departure 20 seconds ahead of no complaints Railroad is still apologizing

                    (Original title: Train opened 20 seconds earlier, Japan Railway Company apologized)
                   

                                   

A Japanese railroad company recently apologized for issuing a statement because a train left the station 20 seconds before the scheduled departure time.

The train from Tsukuba, Tokyo Akihabara station to the full 45 minutes, this should start at 11:44:40 local time, but at 4:44:20 drive. The BBC reported on the 16th that Japan’s Tsukuba Express management made a “sincere apology” for the inconvenience caused. The statement said that the reason for such mistakes, because staff did not seriously check the departure time.

Although no passenger has so far complained about a 20-second advance train departure, the apology was widely forwarded on social media. In Britain, where trains are often delayed, netizens even relayed this apology to local railway companies.

Zimbabwe’s military arrested Mugabe members of the ruling party to impeach the president

                    (Original title: Zimbabwe military arrest Mugabe government members ruling party impeachment President)
                   

                                   According to the AFP, the Zimbabwean military said that some “criminals” in Mugabe’s government have been arrested and the military will continue to hold talks with Mugabe on To step down the issue to communicate.

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According to another Reuters report, Zimbabwe’s ruling African National Alliance, the RPF, will launch a motion on the 17th and plans to remove President Mugabe from office on Sunday (January 19). The news agency quoted senior party officials as saying that if Zimbabwe’s President Mugabe refused to step down, Zimbabwe’s African National Alliance, RPF, will begin the impeachment of Mugabe on the 21st.

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Event Review:

overseas network, according to earlier reports, at 2:00 on the 15th or so, the official residence of the President of Zimbabwe came three to four gunshots, located in Harare, Zimbabwe soldiers and armored vehicles blocked The road to government offices, parliament buildings and courts. When Zimbabwean army chiefs later delivered live broadcasts on state television, he said that the military’s goal is not to be President Mugabe but to criminals who threaten the president. These “criminals” have caused social and economic damage.

The Zimbabwean ruling party has repeatedly stressed that there has been no coup d’état in Zimbabwe but has just gone through a “bloodless regime change” with the seizure of Mugabe and his family “for the country’s constitutional and security considerations” and “Vice President Namanakou Watts will lead the ruling party toward a better future. ”

Over the past three years, the battle over leadership in the post-Mugabe period has intensified within the Zimbabwean ruling party. The two camps emerge, one headed by 75-year-old former Vice President Minanagua, the other headed by 52-year-old First Lady Grace Mugabe. Mugangagua was originally Mugabe’s most likely successor, but on the 6th of this month, Mugabe announced the lifting of Minangaigwa’s position, identifying him as the president of the throne. Prior to the media had reported, Minanga Guwa was dismissed, once I do not know where to go. In the meantime, Zimbabwe’s First Lady Grace Mugabe stated that she is ready to succeed her husband, 93-year-old Robert Mugabe, as president. This series of measures triggered the military dissatisfaction and also laid the groundwork for the recent power change.

According to a report by Reuters on the 16th, President Mugabe, who was under house arrest by the Zimbabwean military, still insists that he is the only legitimate president in Zimbabwe and refuses to accept the military’s mediation was a dignified step down. Reuters quoted a top political official as saying a Fidelis Mukonori priest is currently working as a mediator between the Zimbabwean army and Mugabe. The senior official did not provide Reuters with more details about the conversation between Mugabe and the pastor.

Spain Ministry of Interior: If repatriated to former President Gatai, he may choose a separate cell

                    (Original title: Spain: Optional detention cell if deported to the former President of the Catalan Autonomous Region)
                   

                                   

[World Wide Web Report] Russian satellite network on November 17 citing Catalonia “La Vanguardia” reported that the Spanish Ministry of the Interior in the reply to the Belgian prosecutors said that if the former chairman of Catalonia Autonomous Region Puyi Forced repatriation to Madrid, he can choose a separate cell.

On 3 November, a judge of the Spanish Supreme Court issued an arrest warrant for Pujedmont, Belgium, and other former government members of the Catalan Autonomous Community. The court accused these people of organizing an insurrection, rebellion, misuse of public funds, abuse of power, and disobedience to the government.

Zimbabwe Military: As soon as possible, the outcome of the negotiations with the president will be announced

                    (Original title: Zimbabwe Military: As soon as possible to announce the outcome of the negotiations with the President)
                   

                                   

The Zimbabwe Defense Forces (IDF) today (November 17) adopted a statement by the Zimbabwe National Broadcasting Corporation that it is in talks with President Mugabe and will inform the public as soon as possible. Earlier, Zimbabwe media reported on the 16th that Zimbabwe’s President Mugabe held talks with Zimbabwe’s Defense Minister Qichun Jia on the same day, but no agreement was reached.

Zimbabwe NBC Presidens: ZDF said in a statement that they will include President Mugabe in the negotiations on the future of the country and will inform the public as soon as possible of the outcome of the negotiations.

Zimbabwe The IDF issued a statement through the media that the military’s operations have made significant progress. They took action against a number of criminals living near President Mugabe in order to bring to justice those who were destitute of society and economy in Zimbabwe and others who went unpunished.

The Zimbabwe Defense Forces has also demanded that domestic security forces continue to perform their duties. The military will regularly release news to the media to inform the general public about the changes in the situation in Zimbabwe.

Previous press said the president held talks with the military

Earlier, on the afternoon of the 16th, Zimbabwean President Mugabe took a bus to the presidential palace from his official residence, where he was told Kivenga, Commander of Zimbabwe’s Defense Forces, and his envoy to Zuma, South Africa.

Mugabe’s First Public Appearance Since the Political Situation Changed

The Herald website contains pictures of the talks between Mugabe and Kiwijk and others. This is the first public appearance of Mugabe after the political change in Zimbabwe.

津巴布韦军方:将尽快公布与总统谈判结果

津巴布韦军方:将尽快公布与总统谈判结果

The first human in vivo gene editing treatment is expected to cure the disease

                    (Original title: Human first in vivo gene editing therapy in the United States, is expected to cure Hunter’s syndrome)
                   

                                   

Brian Madeux, a 44-year-old American man, carries nodes that change the history of mankind. According to the Associated Press, on November 13, Dr. Madeleine with Hunter’s syndrome underwent a daring treatment at the University of California, San Francisco, Benioff Children’s Hospital: In Vivo Gene Editing. This is the first in the world to pass genetic editing in the body to treat genetic diseases.

Madeleine, in a casual dress, was stout and on the day of his treatment he wore a cap to cover the top of his head, elevated by illness. It appears that Madeleine was lying on a bed, receiving an ordinary three-hour infusion, but the transparent liquid flowing into the veins from the infusion tube recorded the determination of mankind to combat the unhealthy genetic disease. Transparent liquid contains adeno-associated virus (AAV), zinc finger nuclease (ZFN) and the normal IDS gene deleted from Madsen, they will do something unprecedented.

人类首例体内基因编辑治疗实施 有望治愈这一疾病
Brian Madeux is undergoing treatment. Source: Associated Press.

And CAR-T, etc. After taking the patient’s cells for transformation and transfusion, or using AAV to introduce cDNA for functional protein expression in vivo, Madh treated this more thoroughly and his genomic information will be permanent Sexual change.

A month after the treatment is effective there is a preliminary answer. Three months later, the safety and effectiveness of the therapy will be further confirmed.

It is worth mentioning that the gene editing tool used by Madd was zinc finger nuclease instead of the “Gene Monster Cut” CRISPR. Scientists’ research on zinc finger nucleases dates back to the 1980s compared to “metaphase” CRISPRs and is considered the first generation of gene editing tools. Despite the more complex operation of zinc finger nucleases, the accuracy of gene editing is higher due to the longer sequence for localization. The US Food and Drug Administration (FDA) has approved zinc finger nuclease for human clinical trials, and CRISPR is still not allowed.

Madeleine is the first human clinical trial to study therapies with Sangamo Therapeutics codenamed “SB-913”. The trial was licensed by the National Institutes of Health (NIH) Advisory Committee prior to its launch.

San Calgary has secured a number of key patents for zinc finger nucleases and plans to expand the sample for this trial to test more adult patients and ultimately to treat patients in pediatric patients. Although gene editing can help remove the root causes of the disease, the damage he has done over the past 40 years is irreparable and interventions are therefore more effective from childhood.

Hunter’s Syndrome

Hunter’s syndrome is a rare genetic disorder. The incidence is predominantly male, with one in 100,000 to 170,000 newborn boys suffering from Hunter syndrome.

Every patient with Hunter’s syndrome is deficient in the IDS gene. The gene is not available, and its job is to create an enzyme that breaks down toxic carbohydrates. Due to the absence of the IDS gene, this enzyme deficiency, which acts as a “cleaner”, causes the cells to accumulate toxic metabolites. These “junk” pile up more and more, to bring devastating blow to the patient’s organs.

Most of the patients died before the age of 20, compared to Mad’s condition. Despite this, Mad has so far experienced over 20 surgeries. Last year, bronchial inflammation and pulmonary inflammation almost took his life, his trachea has been distorted, secretions can not be cleared by coughing. Even more unfortunate is that physicians are at a loss as the Hunt’s syndrome suffers from incomplete genetic maps. The only way to alleviate the condition is to enter the patient’s body with the missing enzyme weekly. As a stopgap measure, enzyme replacement therapy costs between $ 100,000 and $ 400,000 per person per year.

“We cut off the DNA, opened a hole, inserted a (normal) gene, and then weighed it. You can not see the traces of the patch and it will be part of your DNA, and you Spend the rest of their lives. “Santeeon CEO Sandy Macrae told the Associated Press so in an interview, so describe their treatment.

Since Hunter’s syndrome is a lack of IDS genes, then the cure is “lack of what to do.”

After entering the body from the veins, the non-pathogenic adeno-associated virus (AAV) acts as a “car” and carries two zinc finger nucleases and one normal gene, reaching Madh’s liver cells. The car was designed to only go to the liver as a “destination.” After reaching the interior of the liver cells, zinc finger nuclease first turns on the GPS function to find the “homework point” accurately and then incarnate “scissors” to cut the double-stranded DNA into the normal gene. By DNA self-repair mechanism, the original DNA fragment to “accommodate” the new normal gene.

According to reports, only 1% of liver cells successfully receive new normal genes, Matthew’s Hunter’s syndrome can be effectively treated.

For Madh, even if the treatment is effective, the damage from the disease over the past few decades has been irreversible. In addition, the journal Science points out that the gene therapy may have the same predilection as enzyme replacement therapy: failure to cross the blood-brain barrier and a barrier that prevents many substances from entering the brain through the bloodstream. This means that Mad’s brain damage may not be contained.

Up-and-down Gene Therapy

Although the safety of zinc finger nucleases has been repeatedly tested, the therapy has been well validated in animal models prior to testing on Madeleine. But when it comes to gene therapy, people still can not take it lightly. Is this foolproof this time?

This concern is not without its cause. In the early nineties of the last century, gene therapy was once the darling of the scientific community, many human experiments hot. But “accidental” at the expense of life splashes gene therapy.

In 1999, Jesse Gelsinger, a 18-year-old American boy with ornithine carbamoyltransferase deficiency, died of an unfortunate clinical trial of a gene therapy because of the immune response Cytokine storm coming.

Belgian court trial within 10 days to decide whether to repatriate the former President of Thailand

                    (Original title: Belgian court trial within 10 days to decide whether to repatriate former Catalan President)
                   

                                   

比利时法庭开审 10日内决定是否遣返加泰前主席

Overseas Network November 17 – Spain’s former Catalan President Puigmonte launched an independent referendum in October and was later wanted by the Central Government of Madrid in order to incite rebellion and other crimes so far Stay in Belgium. The Brussels court in Belgium announced the hearing on Friday (January 17), hearing whether the repatriation of Puigmonte would be returned.

The Brussels Tribunal announced the hearing on Friday to decide whether to remand Spain, the leader of Catalonia, which was laid off, to Puigmonte and four former cabinet members, the Russian satellite news agency reported.

According to reports from the Hong Kong East Network, judges of the Brussels court will hold a secret hearing to hear counsel from both parties. Michelle Hirsch, two of the sought-after former cabinet members in the self-government administration, said she would ask judges in the Belgian Brussels court to respect the fundamental rights of EU citizens. Hirsch emphasized that organizing a referendum is not a criminal offense but rather a way of expressing political opinions.

Allegedly, the results of the first instance will be announced within 10 days. If the judge ruled that extradition should be allowed, Pleumonte and his allies still have the right to appeal. The outside world expects the case will be a protracted war, the defeated party will certainly appeal in the end.

President Mugabe made his first public appearance after being detained by Zimbabwean military forces

                    (Original title: President Mugabe made his first public appearance since being detained by the Zimbabwe military)
                   

                                   

60040056565.jpg
Mugabe appeared at a college graduation ceremony. (Source: Associated Press)

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Mugabe

overseas network November 17 electric u0026 nbsp; Reuters updates today (17) after being detained by the military Zimbabwean President Robert Mugabe The first public appearance appeared at a graduation ceremony at a university in Harare.

According to earlier reports from overseas websites, at about 2 a.m. on the 15th, thirty or forty shots were heard at the Zimbabwean President’s residence and soldiers and armed vehicles in Harare, capital of Zimbabwe, blocked access to Government offices, parliament buildings and courts. When Zimbabwean army chiefs later delivered live broadcasts on state television, he said that the military’s goal is not to be President Mugabe but to criminals who threaten the president. These “criminals” have caused social and economic damage.

The Zimbabwean ruling party has repeatedly stressed that there has been no coup d’état in Zimbabwe but has only gone through a “bloodless regime change” with the seizure of Mugabe and his family “for the country’s constitutional and security considerations” and “Vice President Namanakou Watts will lead the ruling party toward a better future. ”

Over the past three years, the battle over the leadership of the post-Mugabe period in Zimbabwe’s ruling party has intensified. The two camps emerge, one headed by 75-year-old former Vice President Minanagua, the other headed by 52-year-old First Lady Grace Mugabe. Mugangagua was originally Mugabe’s most likely successor, but on the 6th of this month, Mugabe announced the lifting of Minangaigwa’s position, identifying him as the president of the throne. Prior to the media had reported, Minanga Guwa was dismissed, once I do not know where to go. In the meantime, Zimbabwe’s First Lady Grace Mugabe stated that she is ready to succeed her husband, 93-year-old Robert Mugabe, as president. This series of measures triggered the military dissatisfaction and also laid the groundwork for the recent power change.

According to a report by Reuters on the 16th, Mugabe, who was under house arrest by the Zimbabwean military, still insists that he is the only legitimate president in Zimbabwe and refuses to accept the military’s mediation. Reuters quoted a top political official as saying a Fidelis Mukonori priest is currently working as a mediator between the Zimbabwean army and Mugabe. The senior official did not provide Reuters with more details about the conversation between Mugabe and the pastor.

The BBC reported that a Zanu-PF representative to the United Kingdom told the BBC that Mugabe could hold the power nominally until December’s party congress, where the former Vice President Minangarwa Will officially become the leader of the ruling party and state.

In addition, Morgan Tsvangirai, leader of the Zimbabwean opposition Democratic Change Movement (MDC) who previously received cancer treatment in the UK and South Africa, returned to the capital Harare on the 15th.

At least 20 people were injured in a fire in an elderly community in Pennsylvania, U.S.A.

                    (Original title: At least 20 people were injured in a fire in Pennsylvania, USA – Xinhuanet)
                   

                                   

WASHINGTON, November 17 (Xinhua) At a local community in Chester, Pennsylvania, a retired community died on the night of the 16th, killing at least 20 people.

It is reported that a fire broke out in an aged community in West Chester at about 11 pm local time on the night of 16th. The rapid spread of fire to many buildings clearly revealed the flames emerging from the roofs and windows of buildings.

After the fire, residents in the community quickly evacuated, but many of the evacuees still remained outside in the cold.

Local fire rescue forces and Red Cross rescue teams reportedly arrived on the scene to begin rescue operations. Cheshire County Emergency Department said at least 20 people have been taken to hospital for treatment.

The cause of the fire is currently under investigation.

Korean court for the third time issued Cui Shun real arrest warrant: worried she ran

                    (Original title: Korean court issued Cui Shun Shi third arrest warrant: worried she ran)
                   

                                   

8.jpg Cui Shun real (data plan)

overseas network November 17 electric u0026 nbsp; according to Yonhap news agency reported, local time on the 17th, South Korean court to worry about escaping the grounds to issue an arrest warrant for Choi Shun real, An Zhongfan again . It is reported that this is the third time South Korean court issued a warrant on Cuishun Shi.

According to Yonhap news agency, on the morning of the 14th local time, the Seoul High Court of Justice ruled on the case of “special enrollment” in the actress Cheng Weiluo, Cui Shunshi, the protagonist of “Catechists”, and rejected the appeal of the defendant Cui Shunshi and upheld the arrest of the Seoul Central District Court on suspicion of impeding operations The conviction was sentenced Cui Shun 3 years in prison. In addition, Cui Jingji, former president of Ewha Womans University, was sentenced to 2 years in prison for the first instance.

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